Before treatment begins, it is necessary to inform the treating doctor about all the medicines an individual is taking so that proper dose adjustments can be made; moreover, every medicine interacts with others, and if the doctor has a complete list of your medicines, he/she can tell you which ones have to be avoided. While taking Lasix, it is likely that you will get relief very soon, but you must continue to take it even if you feel well, unless your physician tells you otherwise.
Some of the drugs that interact with Lasix are:-
Aminoglycoside antibiotics [such as Gentamicin, Tobramycin] with Furosemide are avoided, as it can increase the adverse effects of these antibiotics on nerves that control balance and hearing powers. The only exception is when a patient faces a threat to life and has to be administered such antibiotics.
For similar reasons, medicines containing Ethacrynic acid are not recommended with Lasix.
If Lasix is given at the same time to patients who are receiving a high dose of Salicylates, it can lead to salicylate toxicity and cause a temporary hearing loss in patients who have a zinc deficiency.
Digoxin is given to treat certain heart problems, but if Lasix is given at the same time, it can cause hypokalemia or hypomagnesemia; and lead to a decrease in the Digoxin excretion. All these factors can increase Digoxin toxicity, unless serum levels are monitored regularly for such patients.
Administration of Cisapride [which is given to treat Gastroesophageal reflux] with Lasix can also be serious.
Lithium is not recommended with Lasix, since it is related to sodium. Less salt in the body will mean greater retention of Lithium, and when the water level in the body goes down [through the diuresis], it will also hinder release of Lithium, leading to Lithium toxicity.
Antihypertensive drugs such as Doxazosin encourage greater outflow of urine, and if a 'water pill' is given at the same time, it can be dangerous for the patient. For the same reason, patients taking Cisplatin, an anti-cancer medication, who are required to drink a large quantity of fluid [to counter its' side-effects], resulting in frequent urination, cannot take 'water pills' like Furosemide.
Sucralfate, or Indomethacin, may reduce the diuretic and antihypertensive effect of Lasix, as can the cholesterol-reducing medicines - Colestipol and Cholestyramine. It is recommended that intake of these medicines and Lasix should be separated by at least 2 hours.
Antifungals like Amphotericin B induce hypokalemia [lowering of potassium levels in the blood], which Lasix also does, and so these medicines cannot be given concomitantly. The same result occurs if it is taken along with corticosteroids such as Prednisone.
Lasix should not be given alongside NSAIDs as it can lead to changes in the serum creatinine and potassium levels in the patient.
If given with Aspirin, Generic Lasix can temporarily reduce creatinine clearance in patients who have chronic renal insufficiency.
This is not a complete list of the medicines that Lasix interacts with; please consult your doctor for a detailed list.
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